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Images of T cell conjugation

Interactions of T cells (small) with antigen presenting cells (big) shown in phase contrast image (left) and confocal image of tubulin structure (right).

Latest

Phosphonamidate prodrugs of a butyrophilin ligand display plasma stability and potent Vγ9Vδ2 T cell stimulation. N. A. Lentini, B. J. Foust, C. H. Hsiao, A. J. Wiemer, D. F. Wiemer. J Med Chem. 2018. PubMed

 

A new series of butyrophilin prodrugs based on glycine phosphonamidates.

About

Research in the Wiemer lab focuses on early stage drug discovery related to cancer and immunology. We are especially interested in biologically active molecules that can promote anti-cancer immunity. Our research also explores fundamental basic science questions related to immune cell activation, interactions of cancer cells with immune cells, and cell metabolism and signaling. We use a variety of approaches based in chemistry, molecular biology, pharmacology, and immunology. By altering our models with experimental molecules we can enhance our understanding of cellular functions and discover novel drugs and drug targets

Contact

Phone: (860) 486-6717
Address: andrew.wiemer (at uconn.edu)
69 N Eagleville Road
Room 504
Storrs, CT 06269
Follow @WiemerLab
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